Dr Silas Villas-Bôas

Senior Lecturer

Senior Lecturer

Microbiology

Phone: 09-3737599 x83762
Rm 3010/110N
Email: s.villas-boas@auckland.ac.nz

Industrial and Medical Microbiology

My group carries out research on microbial physiology with focus on metabolic mechanisms in living cells. Through a multi-disciplinary approach involving aspects of microbiology, biochemistry, chemistry and engineering, we aim to develop new, cutting edge technologies used to gain insight into the mechanisms governing complex metabolic pathways relevant in industrial fermentation processes, human disease development and in food processes.

Our current research projects and activities are continuously updated at:   http://www.metabolomics.auckland.ac.nz/

Recent Publications

Manpreet K Dhami, Gardner-Gee R, Houtte JV, Villas-Boas SG and Beggs JR (2012). Species-specific chemical signatures from scale insect honeydew. Journal of Chemical Ecology 37(11): 1231-41.
http://www.springerlink.com/content/1669vrt28vmp4187/fulltext.pdf

R Aggio, K Ruggiero and S G Villas-Bôas (2010). Pathway Activity Profiling (PAPi): from the metabolite profile to the metabolic pathway activity. Bioinformatics doi: 10.1093/bioinformatics/btq567, 20210.
http://tinyurl.com/22wdtv4

K F Smart, R B M Aggio, J R Van Houtte & S G Villas-Bôas (2010). Analytical platform for methbolome analysis of microbial cells using methyl chloroformate derivatization followed by gas chromatography-mass spectrometry. NATURE PROTOCOLS, 5(10), 1709-1729, 2010.
http://tinyurl.com/2cux9ok

K Nones and S G Villas-Bôas (2010). Evaluation of the Beneficial Effects of Phytonutrients by Metabolomics. Genetics, Proteomics, and Metabolomics in Nutraceuticals and Functional Foods Chapter 19, 287-296, 2010 Edited by Debasis Bagchi, Francis C. Lau and Manashi Bagchi.
http://tinyurl.com/23fhfmq

S G Villas-Bôas, U Roessner, M Hansen, J Smedsgaard and J Nielsen (Eds). (2007). Metabolome Analysis: An Introduction.. Wiley-Interscience, New Jersey, USA. 320p. Book information: (http://www.wiley.com/WileyCDA/WileyTitle/productCd-0471743445.html) .

S G Villas-Bôas, A Koulman and G A Lane. (2007). Analytical Methods from the perspective of method standardization.. In: Topics in Current genetics - Metabolomics, Jewett, M.C.; and Nielsen J. (Eds). Elsevier-Verlag, Berlin, Germany (in press) .

S G Villas-Bôas and P Bruheim. (2007). Cold glycerol-saline: the topmost quenching solution for accurate intracellular metabolite analysis of microbial cells.. Analytical Biochemistry (in press) doi:10.1016/j.a.b.2007.06.028 .

S G Villas-Bôas and P Bruheim. (2007). The potential of metabolomics tools for bioremediation studies.. OMICS: A Journal of Integrative Biology 11: 305 - 313.

S Mas, S G Villas-Bôas, M E Hansen, M Åkesson, J Nielsen. (2007). A comparison of direct infusion MS and GC-MS for metabolic footprinting of yeast mutants.. Biotechnology and Bioengineering 96: 1014 - 1022.

S G Villas-Bôas, S Noel, G Lane, G Attwood and A Cookson. (2006). Extracellular metabolomics - a metabolic footprinting approach to assess fibre degradation in complex media.. Analytical Biochemistry 349: 297 - 305.

S G Villas-Bôas, J Højer-Petersen, M Åkesson, J Smedsgaard and J Nielsen. (2005). Global metabolome analysis of yeasts: complete evaluation of sample preparation.. Yeast 22: 1155 - 1169 .

S G Villas-Bôas, S Rasmussen and G Lane. (2005). Metabolomics or metabolite profiles?. Trends in Biotechnology 23: 385 - 386.

S G Villas-Bôas, M Åkesson and J Nielsen. (2005). Biosynthesis of glyoxylate from glycine in Saccharomyces cerevisiae.. FEMS Yeast Research 5: 703 - 709.

S G Villas-Bôas, J F Moxley, M Åkesson, G Stephanopoulos and J Nielsen. (2005). High-throughput metabolic state analysis: The missing link in integrated functional genomics of yeasts.. Biochemical Journal 388: 669 - 677.

S G Villas-Bôas, S Mas, M Åkesson, J Smedsgaard and J Nielsen. (2005). Mass spectrometry in metabolome analysis.. Mass Spectrometry Reviews 24: 613 - 646.

R Devantier, B Scheithauer, S G Villas-Bôas, S Pedersen and L Olsson. (2005). Metabolite profiling for analysis of yeast stress response during very high gravity ethanol fermentations.. Biotechnology and Bioengineering 90: 705 - 714. .

G Panagiotou, P Christakopoulos, S G Villas-Bôas and L Olsson. (2005). Fermentation performance and intracellular metabolite profiling of Fusarium oxysporum cultivated on a glucose-xylose mixture.. Enzyme and Microbial Technology 36: 100 - 106. .

<< Our People  < Dr Sue Turner | Professor Michael Walker >